Mechanobiology and Cardiac Maturation
Cells, like all of us, live in a matrix. And the nature of the matrix could determine important functions of the cells, including their shape, migration speeds, fate, proliferative state, as well as metabolism. We focus on understanding how matrix rigidity and topography regulates cell signaling, and metabolism, as well as utilize mechanobiology for cardiac maturation.
Related Publications
Kshitiz, Afzal J, Kim SY, Kim DH (2014). A nanotopography approach for studying the structure-function relationship of cells and tissues, Cell Adhesion & Migration, 8(4). Article
Kshitiz, Afzal J, Kim DH, Levchenko A (2014). Mechanotransduction via p190RhoGAP regulates a switch between cardiomyogenic and endothelial lineages in adult cardiac progenitors, Stem Cells, 32(8), 1999-2007. Article
Ahn EH*, Kim Y*, Kshitiz*, An SS, Afzal J, Lee S, Kwak M, Suh KY, Kim DH, Levchenko A (2014). Spatial control of stem cell fate using nanotopographic cues, Biomaterials, 35(8), 2401-2410. Article
Kshitiz, Afzal J, Kim SY, Kim DH, (2014). A nanotopography approach for studying the structure-function relationships of cells and tissues, Cell Adhesion and Migration, 8(4). Article
Kshitiz*, Hubbi ME*, Ahn EH, Downey J, Kim DH, Rey S, Kundu A, Semenza GL, Abraham RM, Levchenko, A. (2012). Matrix rigidity coordinates the proliferation, differentiation, and morphogenesis of endothelial cells derived from cardiac progenitors, Science Signaling, 5(227):ra41. (Featured as a Article, Highlighted in Science). Article
Kim DH*, Kshitiz*, Smith R, Kim P, Marban E, Suh KY, Levchenko A. (2012). Nanopatterned Cardiac Cell Patches Promote Stem Cell Niche Formation and Myocardial Regeneration, Integrative Biology, 4(9):1019-33. (Featured as a Cover Article). Article
Kshitiz, Kim DH, Beebe D, Levchenko A. (2011). Micro- and nanoengineering for stem cell biology: the promise with a caution, Trends in Biotechnology, 29(8):399-408. Article
Kim DH, Han K, Gupta K, Kwon KW, Suh KY, Levchenko A. (2009). Mechanosensitivity of fibroblast cell shape and movement to anisotropic substratum topography gradients, Biomaterials. 30(29):5433-44. Article